Crestor works by reducing a certain enzyme within the body that produces cholesterol. It belongs to a class of medications called statins.
Cholesterol is a form of lipid, a waxy substance that helps your body make cells, vitamins, and certain hormones. It is not inherently bad. Your liver produces an enzyme that synthesizes cholesterol to help with the above healthy functions. Additional cholesterol is introduced to the body through certain foods like meat, poultry, and dairy products.
There are two types of cholesterol: high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). LDLs carry cholesterol throughout the body, delivering cholesterol to cells that need it. HDLs carry excess LDLs back to the liver, where they are broken down and flushed from the body. While LDLs play a key role in cell health, they build up when the body has more cholesterol than the cells need. This buildup turns into plaque in the arteries (blood vessels). As plaque covers the artery walls, the blood vessels become narrow. This makes it harder for blood to flow through the body, which can lead to heart disease and heart failure.
Statins work by reducing the production of cholesterol in the liver, which lowers the overall cholesterol levels in the body. Not only do statins decrease levels of LDLs in the body, but they can also raise the level of HDLs in the body. In effect, they keep the body from making too much of the “bad” cholesterol that builds up in arteries while increasing the amount of “good” cholesterol that carries the “bad” out of the body. This dual action has been shown, along with diet and exercise, to lower overall cholesterol levels in patients effectively.
Crestor tablets for use over the counterCrestor tablets contain the active ingredient rosuvastatin. Rosuvastatin is typically taken when needed, approximately daily. Your doctor may start you on a low dose and gradually increase your dose as needed. Most Crestor tablets are taken once or twice daily with a meal. Taking more than the recommended dose may cause your stomach to bind as your stomach prepares to take a dose. It is his/her opinion that taking more than the prescribed dose increases the chance your stomach will not work as it should. Your doctor will decide how many dose you need and when.
Common side effects of rosuvastatin include vomiting, diarrhea, loss of appetite, nausea, and abdominal pain. If you experience any severe side effects or allergic reactions, please seek medical attention immediately. Avoid taking more than the prescribed dose for the same condition, even if you feel fine. Rosuvastatin may cause more serious side effects, including infection, infections of the esophagus ( Contains bacteria and fungi), stomach ulcers, and chest pain or pressure. The risk of developing serious side effects may be increased if you miss doses or take a long time to take them. Crestor tablets should not be taken by children or teenagers under the age of 12. Talk to your doctor before taking this medication if you are pregnant or breastfeeding. Crestor tablets are not recommended for use in children below 12 years of age. Crestor should not be used by women or children. Crestor tablets may decrease the effectiveness of medications (including statins) for hypercholesterolemia. This medication may decrease the effectiveness of medications (including statins) for high blood pressure. Talk to your doctor before taking Crestor tablets if you are also taking trandolapril (Tarrangapril), a calcium-channel blocker.
Crestor tablets for heartburnThe dosage of Crestor tablets depends on the type and strength of the medication. The usual dose of Crestor tablets is 50 mg once or twice daily. One Crestor tablet is typically taken once or twice daily. Taking more than the recommended dose can increase the chance of developing serious side effects. Talk to your doctor before taking rosuvastatin if you are also taking trandolapril, a calcium-channel blocker.
Common side effects of rosuvastatin include vomiting, diarrhea, nausea, and abdominal pain or swelling. Avoid taking more than the recommended dose for the same condition, even if you feel fine. Crestor tablets should not be taken by children or teenagers.
The annual sales of Lipitor, AstraZeneca’s cholesterol drug, have been flat across the United States for the past 12 months.
However, the company’s cholesterol drug Crestor, which generated its annual sales of $2.4 billion, is facing a similar issue.
The cholesterol drug Crestor has been linked to the death of more than 3,500 people worldwide in the last 12 months. The deaths were caused by an unusually high number of patients who had already been taking the drug, according to the company’s press release.
The study found that “about 7.5 percent of all patients taking Crestor died of heart problems,” according to a press release.
“We found that the deaths of patients who had suffered heart problems are more likely to be related to the heart disease itself,” said Steven Nissen, a University of Chicago cardiologist who is the chief scientific officer for the drug. “It’s important that these patients are not treated for their underlying heart disease,” Nissen added.
“Statistically speaking, the numbers of heart deaths were higher than for Crestor,” Nissen added. “This is very important because it’s important that patients be able to be monitored in the early stages of heart disease when they are at risk of heart problems.”
A study by researchers from the University of Illinois, Chicago and University of Michigan found that Crestor had a greater risk of death than its generic counterpart in patients with at least one known serious cardiovascular disease. In the study, researchers found that “the incidence of serious cardiovascular disease in patients taking Crestor was significantly higher than in those not taking the drug,” according to the study.
“The study also showed that the risk of serious cardiovascular disease increases with age,” Nissen said.
The study found that Crestor was associated with an annual death rate of about 6.6 times that of the drug’s generic equivalent, the same study found.
“The risk of serious cardiovascular disease increases with longer duration of therapy and higher doses, and the benefit of a more aggressive treatment is substantial,” said Dr. Robert W. Kiehl, director of cardiovascular medicine at the University of Michigan School of Medicine.
Crestor’s use as an oral drug was also examined in a separate study by the drug’s manufacturer, AstraZeneca, in an attempt to test the drug’s ability to reduce the risk of heart attacks and strokes.
“It would be a great opportunity for the public to be informed about the potential benefits of Crestor and its long-term efficacy in preventing heart disease,” Nissen said.
In a separate study, the company’s sales of Lipitor and Crestor were also examined in more than 40 different countries, including the United States, Canada, Australia and New Zealand.
The companies’ prices for the two drugs were also compared. They found that the sales of Crestor were “slightly higher” than Lipitor’s sales of the generic, but the price difference was still statistically significant.
The results were published in the December issue of the journal journal of cardiovascular physiology.
“Crestor is an innovative drug that may offer a new approach to reducing cardiovascular risk,” Nissen added.
Crestor has been linked to the deaths of at least 5,000 patients who developed cardiovascular complications, including heart attacks and strokes. Crestor is the second drug to lose patent protection in the United States.
Originally Published: January 12, 2017 at 7:00 AM PST
Originally published: January 12, 2017 at 7:00 AM PSTThe Crestor and Lipitor studies are both published in the journal.
Crestor (also known as rosuvastatin) is an at-home drug used to treat high blood cholesterol levels. It works by reducing the amount of cholesterol seen in the liver and increasing the body's ability to remove it from the body. Rosuvastatin is available as an oral tablet and injection and is approved for this purpose in 2023. In addition to treating high cholesterol, Crestor also lowers elevated blood fats, including LDL (bad) cholesterol. The medication does not protect against strokes, heart attacks, or breast cancer.
Rosuvastatin is generally safe when used as prescribed. However, it can cause side effects in rare cases. Common side effects may include:
Rare side effects may include:
In addition, Rosuvastatin may cause more serious side effects in certain cases. These side effects may include:
If you experience any severe or persistent side effects, it is important to seek medical help immediately.
When used as prescribed, Rosuvastatin is generally safe when used as prescribed. However, like any medication, it may cause side effects in rare cases.
To use Rosuvastatin correctly, follow these tips:
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